Headaches Everyday: Common

Sunday, December 30, 2012

4 Gene Loci Discovered That Predispose People To The Most Common Subtype Of Migraine

Main Category: Headache / Migraine
Also Included In: Genetics
Article Date: 12 Jun 2012 - 0:00 PDT Current ratings for:
4 Gene Loci Discovered That Predispose People To The Most Common Subtype Of Migraine
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Researchers studied genetic data of more than 11 000 people and found altogether six genes that predispose to migraine without aura. Four of these genes are new and two of them confirm previous findings.

The new genes identified in this study provide further evidence for the hypothesis that dysregulation of molecules important in transmitting signals between brain neurons contribute to migraine. Two of the genes support the hypothesis of a possible role of blood vessels and thus disturbances in blood flow.

The researchers carried out what is known as a genome-wide association study (GWAS) to zoom in on genome variants that could increase susceptibility to migraine; they compared genomes of 4800 migraine patients with more than 7000 non-migraine individuals. The project was performed by the International Headache Genetics Consortium consisting of leading migraine researches from Europe and Australia.

This was the third report on genes predisposing people to common forms of migraine, but the first one on the most common migraine subtype. "The study establishes for the first time a specific gene that contributes to this common disease" said Professor Aarno Palotie at FIMM and the Wellcome Trust Sanger Institute, the chair of the International Headache Genetics Consortium.

The carefully studied migraine patients collected from specialized headache clinics were provided a strong basis for the success of this study.

Migraine affects approximately one in six women and one in eight men, making it a leading cause of work absence and short-term incapacity: 25 million school or work days are lost for migraine each year. A US report measures its economic costs as similar to those of diabetes and WHO lists it as one of the top twenty diseases with the causes of years lived with disability (YLDs). In up to one third of migraine patients, the headache phase may be preceded or accompanied by transient neurological disturbances, the so-called aura (i.e. migraine with aura), while the majority of patients suffer from migraine without aura.

"Studies of this kind are possible only through large-scale international collaboration - bringing together the wealth of data with the right expertise and resources. The identified genes open new doors to investigate how this type of migraine comes about," said Dr. Arn van den Maagdenberg, one of the senior authors on the paper.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Saturday, December 29, 2012

First Study To Refute A Common Health Misconception: Children's Headaches Rarely Indicate A Need For Eyeglasses

Main Category: Headache / Migraine
Also Included In: Pediatrics / Children's Health; Eye Health / Blindness
Article Date: 14 Nov 2012 - 0:00 PST Current ratings for:
First Study To Refute A Common Health Misconception: Children's Headaches Rarely Indicate A Need For Eyeglasses
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A new study provides the first clear evidence that vision or eye problems are rarely the cause of recurring headaches in children, even if the headaches usually strike while the child is doing schoolwork or other visual tasks. Many parents assume that frequent headaches mean their child needs glasses, so they ask their doctor to refer their child for an eye exam. This study was conducted by pediatric ophthalmologists who wanted to find reliable answers for parents, family doctors and pediatricians facing this common health question. The research was presented at the 116th Annual Meeting of the American Academy of Ophthalmology, conducted jointly this year with the Asia-Pacific Academy of Ophthalmology.

In this retrospective study, which was conducted at the ophthalmology clinic of Albany Medical Center in New York state, researchers reviewed the medical records of 158 children under age 18 who were seen at the clinic for frequent headaches from 2002-11. All of the children received complete eye exams by the clinic's ophthalmologists.

No significant correlation was found between their frequent headaches and a need for vision correction. The researchers reached this conclusion by comparing the results of the clinic's exams of the children with headaches to the records of their previous eye exams and other relevant medical care. Eye health and vision test results remained unchanged from earlier exams for 75 percent of the children. Also, children who already had eyeglasses were not found to need new prescriptions at the time they were seen at the clinic for headaches. Although about 14 percent of the children reported that their headaches occurred while doing visual tasks like homework, and about nine percent reported visual symptoms associated with their headaches, a need for vision correction did not appear to be the primary cause or a significant factor in any of these cases, according to the study.

The researchers considered it positive that most of the children's headaches resolved over time. Follow up reports from parents showed that headaches improved in 76.4 percent of all study subjects, including those who did and those who did not receive new vision correction prescriptions. Children who received new prescriptions were not more likely than others to have their headaches improve. Assessing the causes of the headaches and addressing the children's long-term outcomes were beyond the scope of this study.

"We hope our study will help reassure parents that in most cases their children's headaches are not related to vision or eye problems, and that most headaches will clear up in time," said Zachary Roth, M.D., who led the research team. "The information should also be useful to family doctors and pediatricians in caring for children and parents who have this common health concern."

About thirty percent of the children in the study had eye conditions that went beyond the need for vision correction, including strabismus (misaligned eyes) amblyopia ("lazy eye") or other rarer, more serious conditions. Seventeen percent had a family history of migraine. Because this was a retrospective study, the researchers were unable to connect these factors with headache causes.